Natural Factors BioCoenzymated Methylfolate Plus Methylcobalamin B12 represents the next generation of nutritional supplements, providing bioactive forms of two essential B vitamins.
This one-a-day formula features coenzymated forms of folate and vitamin B12 – two vital nutrients needed for normal early fetal development, energy metabolism, red blood cell production, and to help maintain cardiovascular and cognitive health.
Quatrefolic L-5-Methyltetrahydrofolic acid (L-5-MTHF) is a metabolically active and coenzymated form of folate. Preformed coenzyme forms of B vitamins offer immediate, direct nutritional support – even for those with genetic differences that impair metabolism of standard B vitamins. Emerging research has shown that Quatrefolic ensures a higher folate uptake and can help increase blood folate levels more effectively than regular folic acid.
This unique biocoenzymated formula features proprietary EnviroSimplex technology, combining Farm Fresh Factors, an organic whole food blend of land and sea vegetables, with the coenzyme form of the B vitamins. The result is a synergistic phytochemical formula that delivers the most metabolically active nutrients to your cells.
Natural Factors BioCoenzymated Methylfolate is gluten free, non-GMO, suitable for vegetarians, and sublingual – no need to swallow pills! This advanced formula is ideal for anyone who wants the highest quality, most bioactive forms of these two key nutrients.


Helps support normal early fetal development
Helps prevent folate deficiency
Helps produce red blood cells
Sublingual delivery system ideal for customers who dislike swallowing pills
A factor in the maintenance of good health